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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12336991 B1

PDFFull Text
Date of Patent:
Jun. 24, 2025

Filed:

Mar. 28, 2019

Factor xiia inhibitors

Applicant:

University of Leeds, Leeds, GB;

Inventors:

Helen Philippou, Leeds, GB;

Richard Foster, Leeds, GB;

Colin Fishwick, Leeds, GB;

Charlotte Revill, Leeds, GB;

Ian Yule, Leeds, GB;

Roger Taylor, Leeds, GB;

Alan Naylor, Harston, GB;

Philip Spencer Fallon, Saffron Walden, GB;

Stuart Crosby, Saffron Walden, GB;

Anna Hopkins, Saffron Walden, GB;

Lucie Juliette Guetzoyan, Saffron Walden, GB;

Alistair James Macnair, Saffron Walden, GB;

Mark Richard Stewart, Saffron Walden, GB;

Natalie Louise Winfield, Saffron Walden, GB;

Assignee:

University of Leeds, , GB;

Attorney:

Shackelford, Mckinley & Norton, LLP

Primary Examiner:

Ana Z Muresan

Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/40 (2006.01); A61K 31/4192 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61P 7/02 (2006.01); C07D 207/16 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/40 (2013.01); A61K 31/4192 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61P 7/02 (2018.01); C07D 207/16 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 471/04 (2013.01);
Abstract

This invention relates to compounds of formula (I) and methods of treatment using the compounds. The invention also relates to processes and methods for producing the compounds of the invention. The compounds of the invention are modulators of Factor XII (e.g. Factor XIIa). In particular, the compounds are inhibitors of Factor XIIa and may be useful as anticoagulants.

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