The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2025
Filed:
Jun. 17, 2024
Applicant:
Arcutis Biotherapeutics, Inc., Westlake Village, CA (US);
Inventor:
David W. Osborne, Fort Collins, CO (US);
Assignee:
ARCUTIS Biotherapeutics, Inc., Westlake Village, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/14 (2006.01); A61K 45/06 (2006.01); A61K 47/10 (2017.01); C09K 15/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/44 (2013.01); A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 9/145 (2013.01); A61K 45/06 (2013.01); A61K 47/10 (2013.01); C09K 15/06 (2013.01);
Abstract
Roflumilast crystals have been shown to increase in size during storage. The size of the roflumilast crystals can affect the bioavailability and efficacy of a pharmaceutical composition. The growth of roflumilast crystals can be inhibited during storage by including hexylene glycol in the composition. The resulting composition has improved bioavailability and efficacy and can be used to inhibit phosphodiesterase 4 in patient in need of such treatment.