The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2025
Filed:
Feb. 10, 2021
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Jayaram K. Udupa, Philadelphia, PA (US);
Yubing Tong, Springfield, PA (US);
Drew A. Torigian, Philadelphia, PA (US);
You Hao, Philadelphia, PA (US);
Changjian Sun, Philadelphia, PA (US);
Joseph M. McDonough, Ambler, PA (US);
Patrick J. Cahill, Merion Station, PA (US);
The Children's Hospital of Philadelphia, Philadelphia, PA (US);
Abstract
A method of analyzing thoracic insufficiency syndrome (TIS) in a subject by performing quantitative dynamic magnetic resonance imaging (QdMRI) analysis. The QdMRI analysis includes performing four-dimensional (4D) image construction of a TIS subject's thoracic cavity. The 4D image includes a sequence of two dimensional (2D) images of the TIS subject's thoracic cavity over a respiratory cycle of the TIS subject. The QdMRI analysis also includes segmenting a region of interest (ROI) within the 4D image, determining TIS measurements within the ROI, comparing the TIS measurements to normal measurements determined from ROIs in 4D images of the thoracic cavities of normal subjects that are not afflicted by TIS, and outputting quantitative markers indicating deviation of the thoracic cavity of the TIS subject relative to the thoracic cavities of the normal subjects.