The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2025
Filed:
Apr. 04, 2022
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Shadia Abike Oshodi, Jersey City, NJ (US);
Amy S. Johnson, Briarcliff Manor, NY (US);
Shawn M. Lawrence, Nyack, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C07K 16/18 (2006.01); C12N 5/071 (2010.01); C12P 21/00 (2006.01);
U.S. Cl.
CPC ...
C12P 21/00 (2013.01); C07K 16/18 (2013.01); C12N 5/0031 (2013.01); C12N 5/0037 (2013.01); C12N 5/0043 (2013.01); C12N 5/005 (2013.01); C12N 5/0682 (2013.01); C12N 2500/22 (2013.01); C12N 2500/24 (2013.01); C12N 2500/32 (2013.01); C12N 2500/34 (2013.01); C12N 2500/46 (2013.01); C12N 2510/02 (2013.01); C12N 2511/00 (2013.01);
Abstract
The specification describes an improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Ornithine, or a combination of ornithine and putrescine can be added to serum-free media or chemically defined media to improve viable cell density, to reduce cell doubling time, and to increase the production of a protein of interest.