The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2025
Filed:
Feb. 10, 2023
Vertex Pharmaceuticals Incorporated, Boston, MA (US);
Edwin L. Madison, San Francisco, CA (US);
Christopher Thanos, Tiburon, CA (US);
Vanessa Soros, San Francisco, CA (US);
Mikhail Popkov, San Diego, CA (US);
Kimberly Tipton, Boston, MA (US);
Matthew John Traylor, Boulder, CO (US);
Eric Steven Furfine, Lincoln, MA (US);
Jeffrey Charles Way, Cambridge, MA (US);
Vertex Pharmaceuticals, Incorporated, Boston, MA (US);
Abstract
Provided are nucleic acid molecules, including vectors and plasmids, encoding modified u-PA polypeptides and fusion proteins containing the modified u-PA polypeptides. The u-PA polypeptides are modified to have altered activity and/or specificity so that they cleave a complement protein, such as complement protein C3, to thereby inhibit complement activation. The nucleic acids and encoded modified u-PA polypeptides and fusion proteins that inhibit complement activation can be used for treatment of diseases and conditions that are mediated by complement activation, or in which complement activation plays a role. These disorders include ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, diabetic retinopathies, age-related macular degeneration, transplanted organ rejection, inflammatory diseases and diseases with an inflammatory component.