The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 17, 2025

Filed:

Apr. 12, 2018
Applicants:

The Broad Institute, Inc., Cambridge, MA (US);

The General Hospital Corporation, Boston, MA (US);

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Jayaraj Rajagopal, Boston, MA (US);

Aviv Regev, Cambridge, MA (US);

Moshe Biton, Cambridge, MA (US);

Adam Haber, Cambridge, MA (US);

Daniel Montoro, Boston, MA (US);

Orit Rozenblatt-Rosen, Cambridge, MA (US);

Assignees:

THE BROAD INSTITUTE, INC., Cambridge, MA (US);

THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); A61K 35/42 (2015.01); A61P 11/00 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0688 (2013.01); A61K 35/42 (2013.01); A61P 11/00 (2018.01); G01N 33/5044 (2013.01); C12N 2501/42 (2013.01); C12N 2506/27 (2013.01);
Abstract

Provided herein are methods and compositions for identifying ionocytes from respiratory epithelial cells, and uses of such cells for treatment of inflammatory lung disease. Also provided herein are methods and compositions for modulating respiratory tract epithelial cell proliferation, differentiation, maintenance, and/or function.


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