The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2025
Filed:
Nov. 17, 2021
Applicant:
Ucl Business Ltd, London, GB;
Inventors:
John Anderson, London, GB;
Jonathan Fisher, London, GB;
Martin Pulé, London, GB;
Kenth Gustafsson, London, GB;
Assignee:
UCL Business Ltd, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 40/31 (2025.01); A61K 40/11 (2025.01); A61K 40/42 (2025.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0638 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4202 (2025.01); A61K 40/4258 (2025.01); A61P 31/04 (2018.01); A61P 31/12 (2018.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C12N 5/0636 (2013.01); A61K 2239/28 (2023.05); A61K 2239/29 (2023.05); C12N 2501/599 (2013.01); C12N 2510/00 (2013.01);
Abstract
The present invention provides a T cell which expresses a gamma-delta T cell receptor (TCR) and a chimeric antigen receptor (CAR), wherein the CAR comprises: an antigen binding domain; a transmembrane domain; and a co-stimulatory intracellular signalling domain; wherein the intracellular signalling domain provides a co-stimulatory signal to the T cell following binding of antigen to the antigen binding domain.