The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2025
Filed:
Oct. 12, 2022
Institute for Basic Science, Daejeon, KR;
Korea Advanced Institute of Science and Technology, Daejeon, KR;
Gou Young Koh, Daejeon, KR;
Jeomil Bae, Daejeon, KR;
Mi Jeong Kim, Daejeon, KR;
Jin-Sung Park, Daejeon, KR;
Su Jin Seo, Daejeon, KR;
Jaeryung Kim, Daejeon, KR;
Jang Ryul Park, Daejeon, KR;
Pilhan Kim, Daejeon, KR;
Wangyuhl Oh, Daejeon, KR;
Institute for Basic Science, Daejeon, KR;
Korea Advanced Instritute of Science and Technology, Daejeon, KR;
Abstract
The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention further provides an angiogenesis inhibitor and a composition for treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.