The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2025
Filed:
Apr. 10, 2019
Bayer Aktiengesellschaft, Leverkusen, DE;
Anke Mayer-Bartschmid, Wülfrath, DE;
Damian Brockschnieder, Haan, DE;
Marcel Geertz, Remscheid, DE;
Simone Greven, Dormagen, DE;
Lucas Hudson Hofmeister, Wuppertal, DE;
Hannah Jörissen, Heiligenhaus, DE;
Christoph Mahlert, Wuppertal, DE;
Tobias Marquardt, Wuppertal, DE;
Ilka Mathar, Düsseldorf, DE;
Thomas Mondritzki, Essen, DE;
Claudia Noack, Berlin, DE;
Jan Tebbe, Cologne, DE;
Stuart Walsh, Hamburg, DE;
Ernst Weber, Langenfeld, DE;
Andreas Wilmen, Cologne, DE;
Frank Wunder, Wuppertal, DE;
Bayer Aktiengesellschaft, Leverkusen, DE;
Abstract
The present invention relates to an antibody or a fragment thereof comprising at least one heterologous amino acid sequence incorporated within at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Nils), an Atrial Natriuretic Peptide (ANP) and a C-terminal linker sequence (Ctls). Optionally, at least a portion of said at least one CDR region is replaced by said at least one heterologous amino acid sequence incorporated therein. The present invention further relates to such antibody or fragment thereof for use in a method for treatment, a composition comprising such antibody or fragment thereof, a nucleic acid or a mixture of nucleic acids encoding such antibody or fragment thereof, a host cell comprising such nucleic acid or such mixture of nucleic acids and to a process for producing such antibody or fragment thereof.