The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 17, 2025

Filed:

Mar. 18, 2021
Applicant:

Karyopharm Therapeutics Inc., Newton, MA (US);

Inventors:

Erkan Baloglu, Stoneham, MA (US);

Sharon Shacham, Newton, MA (US);

William Senapedis, Millis, MA (US);

Dilara McCauley, Arlington, MA (US);

Yosef Landesman, Brookline, MA (US);

Gali Golan, Mesilat Zion, IL;

Ori Kalid, Pardes Hanna, IL;

Sharon Shechter, Andover, MA (US);

Assignee:

Karyopharm Therapeutics Inc., Newton, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); C07D 307/81 (2006.01); C07D 405/12 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 491/048 (2006.01); C07D 491/08 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); C07D 307/81 (2013.01); C07D 405/12 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 491/048 (2013.01); C07D 491/08 (2013.01);
Abstract

The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula A: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.


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