The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 17, 2025

Filed:

Jun. 07, 2019
Applicant:

The Board of Trustees of the University of Illinois, Urbana, IL (US);

Inventors:

Bin He, Chicago, IL (US);

Xing Liu, Chicago, IL (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/763 (2015.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C12N 7/00 (2006.01); C12N 15/09 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
A61K 35/763 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C12N 7/00 (2013.01); C12N 15/09 (2013.01); C12N 15/63 (2013.01); C12N 2710/16621 (2013.01); C12N 2710/16632 (2013.01);
Abstract

A method for treating a subject with cancer by administering to the subject a therapeutically effective amount of a recombinant Herpes Simplex Virus-1 (HSV-1) that expresses only a C-terminal portion of γ34.5 protein (e.g., amino acid residues 147-263) with no wild-type or intact γ34.5 protein expression is provided. The recombinant HSV-1 of this invention instigates immune activation, selectively replicates in cancer cells, and resists clearance by interferon.


Find Patent Forward Citations

He, Bin. (2025). Recombinant herpes simplex virus for cancer immunotherapy (U.S. Patent No. 12329794). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12329794

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…