The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 17, 2025
Filed:
Apr. 30, 2018
William Marsh Rice University, Houston, TX (US);
Board of Regents, the University of Texas System, Austin, TX (US);
Baylor College of Medicine, Houston, TX (US);
Houston Methodist Research Institute, Houston, TX (US);
The United States Government, Washington, DC (US);
James M. Tour, Bellaire, TX (US);
Lizanne Nilewski, La Jolla, CA (US);
William Sikkema, Langley, CA;
Kimberly Mendoza, Houston, TX (US);
Thomas Andrew Kent, Houston, TX (US);
William Dalmeida, Jr., League City, TX (US);
Paul J. Derry, Houston, TX (US);
Ah-Lim Tsai, Sugarland, TX (US);
Muralidhar L. Hegde, Houston, TX (US);
Prakash Dharmalingam, Houston, TX (US);
Pavana Dixit Hegde, Houston, TX (US);
Sankar Mitra, Houston, TX (US);
Joy Mitra, Houston, TX (US);
William Marsh Rice University, Houston, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Baylor College of Medicine, Houston, TX (US);
Houston Methodist Research Institute, Houston, TX (US);
The United States Government, Washington, DC (US);
Abstract
Modified hydrophilic carbon clusters (HCCs), poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) and similarly structured materials like graphene quantum dots (GQDs), PEGylated GQDs, small molecule antioxidants, and PEGylated small molecule antioxidants. These materials have been modified with an iron chelating moiety, deferoxamine, or a similar chelating moiety. By exploiting common binding sites, the carbon nanostructure facilitates intracellular transport including in mitochondria, reduces oxidative breakdown of the chelator moiety prior to treatment, and reduces both the cause and consequences of metal induced oxidative stress within the body thus providing a novel form of therapy for a range of oxidative and metal-related toxicities. Graphenic materials can be used for the treatment of acute and chronic mitochondrial electron transport chain dysfunction.