The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 10, 2025

Filed:

Jan. 23, 2019
Applicant:

Virginia Commonwealth University, Richmond, VA (US);

Inventors:

Paul B. Fisher, Henrico, VA (US);

Mitchell E. Menezes, Richmond, VA (US);

Praveen Bhoopathi, Richmond, VA (US);

Swadesh K Das, Richmond, VA (US);

Luni Emdad, Richmond, VA (US);

Devanand Sarkar, Richmond, VA (US);

Anjan K. Pradhan, Richmond, VA (US);

Xiang-Yang Wang, Richmond, VA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 31/5377 (2006.01); A61K 35/17 (2015.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/54 (2006.01); C07K 14/62 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 31/5377 (2013.01); A61K 35/17 (2013.01); A61K 39/4611 (2023.05); A61K 39/4635 (2023.05); A61K 39/4644 (2023.05); A61P 35/00 (2018.01); C07K 14/54 (2013.01); C07K 14/62 (2013.01); A61K 38/00 (2013.01); A61K 2239/31 (2023.05); A61K 2239/49 (2023.05); A61K 2239/55 (2023.05); A61K 2239/58 (2023.05);
Abstract

In various aspects, the present disclosure provides polynucleotides encoding a fusion protein, as well as vectors, cells, and compositions comprising the same. In embodiments, the fusion protein includes an insulin signal peptide and an MDA-7/IL-24 protein. Methods of using the polynucleotides, vectors, cells, and compositions, such as in the treatment or prevention of cancer, are also provided.


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