The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 10, 2025

Filed:

Dec. 20, 2021
Applicant:

The Kennedy Trust for Rheumatology Research, London, GB;

Inventors:

Mervyn Maze, San Francisco, CA (US);

Marc Feldmann, London, GB;

Niccolo Terrando, San Francisco, CA (US);

Mario Cibelli, London, GB;

Daqing Ma, London, GB;

Michael Fertleman, London, GB;

Jagdeep Nanchahal, Oxford, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/24 (2006.01); A61K 31/546 (2006.01); A61K 31/713 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); C07K 14/525 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C07K 16/241 (2013.01); A61K 31/546 (2013.01); A61K 31/713 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); C07K 14/525 (2013.01); C12N 15/113 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/76 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01);
Abstract

The present invention provides method, uses and agents for preventing or reducing cognitive decline in a patient following a planned inflammatory trigger. Such planned inflammatory trigger can be a surgical procedure or chemotherapy. The invention further provides methods, uses and agents for reducing cognitive decline in a patient with a cognitive disorder, wherein said patient has been exposed to an inflammatory trigger. Pharmaceutical compositions and kits are also provided.


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