The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2025
Filed:
Dec. 13, 2022
Applicant:
Lanova Medicines Limited Company, Shanghai, CN;
Inventor:
RunSheng Li, Shanghai, CN;
Assignee:
LaNova Medicines Limited Company, Shanghai, CN;
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6817 (2017.08); A61K 47/68031 (2023.08); A61K 47/6849 (2017.08); A61P 35/00 (2018.01);
Abstract
Provided are antibody-drug conjugates containing a drug moiety attached to an antibody or fragment thereof having binding specificity to the wild-type human claudin 18.2 (CLDN18.2) protein. The antibody or the fragment thereof binds to the β3-β4 loop (residues 45-63 of SEQ ID NO: 30, NYQGLWRSCVRESSGFTEC) and the β5 strand (residues 169-172 of SEQ ID NO: 30, YTFG) of CLDN18.2.