The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 10, 2025
Filed:
May. 07, 2019
Genmab A/s, Valby, DK;
Msd International Gmbh, Lucerne, CH;
Reshma Abdulla Rangwala, Philadelphia, PA (US);
Esther C. W. Breij, Driebergen, NL;
Sandra Verploegen, Nieuwegein, NL;
Oyewale O. Abidoye, Bellevue, WA (US);
Leonardo Viana Nicacio, Redmond, WA (US);
Anthony Cao, Sammamish, WA (US);
Shyra Gardai, Bothell, WA (US);
GENMAB A/S, Valby, DK;
MSD INTERNATIONAL GMBH, Luzerne, CH;
Abstract
The invention provides an anti-PD-1 antibody comprising the complementary determining regions (CDRs) of pembrolizumab in combination with an antibody-drug conjugate that binds to tissue factor (TF) comprising monomethyl auristatin E and the CDRs of tisotumab (e.g., tisotumab vedotin) and their use in methods of treating cancer, such as breast cancer and cervical cancer. The invention also provides compositions and kits comprising the anti-PD-1 antibody comprising the CDRs of pembrolizumab and the antibody-drug conjugate that binds to TF comprising monomethyl auristatin E and the CDRs of tisotumab (e.g., tisotumab vedotin) for use in treating cancer, such as breast cancer and cervical cancer.