The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 10, 2025

Filed:

Nov. 17, 2021
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

Jeremy J. Clemens, San Diego, CA (US);

William Schulz Bechara, Laval, CA;

Brett C. Bookser, San Diego, CA (US);

Thomas Cleveland, San Marcos, CA (US);

Timothy R. Coon, Carlsbad, CA (US);

Michel Gallant, Pierrefonds, CA;

Peter Grootenhuis, Del Mar, CA (US);

Sara Sabina Hadida Ruah, La Jolla, CA (US);

Julie Laterreur, San Diego, CA (US);

Mark Thomas Miller, Rancho Santa Fe, CA (US);

Prasuna Paraselli, San Diego, CA (US);

Yeeman K. Ramtohul, Pierrefonds, CA;

Thumkunta Jagadeeswar Reddy, Pierrefonds, CA;

Claudio Sturino, Ile Bizard, CA;

Lino Valdez, San Diego, CA (US);

Jinglan Zhou, San Diego, CA (US);

Minson Baek, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/436 (2006.01); A61K 31/404 (2006.01); A61K 31/439 (2006.01); A61K 31/443 (2006.01); A61K 31/4439 (2006.01); A61K 31/4995 (2006.01); A61K 31/529 (2006.01); A61P 3/00 (2006.01); A61P 43/00 (2006.01); C07D 498/18 (2006.01); C07D 498/22 (2006.01); C07D 515/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/439 (2013.01); A61K 31/404 (2013.01); A61K 31/443 (2013.01); A61K 31/4439 (2013.01); A61K 31/4995 (2013.01); A61K 31/529 (2013.01); C07D 498/18 (2013.01); C07D 498/22 (2013.01);
Abstract

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.


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