logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12320734 B1

PDFFull Text
Date of Patent:
Jun. 03, 2025

Filed:

May. 19, 2021

Reagent nozzle sipper mixing system and method

Applicant:

Illumina, Inc., San Diego, CA (US);

Inventors:

Bradley Kent Drews, Poway, CA (US);

Michael Dai Wang, San Diego, CA (US);

Umberto Ulmanella, San Diego, CA (US);

James Michael Osmus, San Diego, CA (US);

Stephen Wayne Clark, San Diego, CA (US);

Johanna Lynn Whitacre, San Diego, CA (US);

Steven Scott Phelps, San Diego, CA (US);

Michelle L. Alvarez, San Diego, CA (US);

Michael Adalbert Niziolek, San Diego, CA (US);

Debra Sue Bryan, San Diego, CA (US);

Joshua Augustin Darland, San Diego, CA (US);

Assignee:

Illumina, Inc., San Diego, CA (US);

Attorney:

Weaver Austin Villeneuve & Sampson LLP

Primary Examiner:

Brian R Gordon

Int. Cl.
CPC ...
G01N 1/38 (2006.01); B01F 3/08 (2006.01); B01F 5/00 (2006.01); B01F 5/06 (2006.01); B01F 11/00 (2006.01); B01F 13/10 (2006.01); B01F 15/00 (2006.01); B01F 15/02 (2006.01); B01F 23/40 (2022.01); B01F 23/45 (2022.01); B01F 25/10 (2022.01); B01F 25/433 (2022.01); B01F 31/65 (2022.01); B01F 33/84 (2022.01); B01F 35/53 (2022.01); B01F 35/71 (2022.01); B01F 35/75 (2022.01); B01L 3/00 (2006.01); C12Q 1/6874 (2018.01); G01N 1/14 (2006.01); G01N 35/10 (2006.01); B01F 101/23 (2022.01);
U.S. Cl.
CPC ...
G01N 1/38 (2013.01); B01F 23/45 (2022.01); B01F 23/49 (2022.01); B01F 25/103 (2022.01); B01F 25/4331 (2022.01); B01F 31/651 (2022.01); B01F 33/84 (2022.01); B01F 35/53 (2022.01); B01F 35/7176 (2022.01); B01F 35/7544 (2022.01); B01L 3/502 (2013.01); B01L 3/502715 (2013.01); B01L 3/502738 (2013.01); B01L 3/527 (2013.01); C12Q 1/6874 (2013.01); G01N 1/14 (2013.01); G01N 35/1002 (2013.01); G01N 35/1095 (2013.01); G01N 35/1097 (2013.01); B01F 2101/23 (2022.01); B01L 3/52 (2013.01); B01L 2200/027 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0832 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/0883 (2013.01); B01L 2400/0644 (2013.01); G01N 2001/1418 (2013.01); G01N 2001/1436 (2013.01); G01N 2001/386 (2013.01); G01N 35/1016 (2013.01); G01N 2035/1058 (2013.01);
Abstract

An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.

Find Patent Forward Citations

Loading…