The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 03, 2025

Filed:

Aug. 24, 2021
Applicants:

Exact Sciences Corporation, Madison, WI (US);

Mayo Foundation for Medical Education and Research, Rochester, MN (US);

Inventors:

David A. Ahlquist, Rochester, MN (US);

William R. Taylor, Lake City, MN (US);

John B. Kisiel, Rochester, MN (US);

Douglas W. Mahoney, Elgin, MN (US);

Tracy C. Yab, Rochester, MN (US);

Graham P. Lidgard, Middleton, WI (US);

Hatim T. Allawi, Middleton, WI (US);

Assignees:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C07H 21/04 (2006.01); C12Q 1/6883 (2018.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6886 (2013.01); C12Q 1/6883 (2013.01); G01N 33/57407 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/154 (2013.01); C12Q 2600/166 (2013.01); G01N 2440/12 (2013.01); G01N 2800/14 (2013.01);
Abstract

Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).


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