The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 03, 2025

Filed:

Jan. 24, 2020
Applicant:

Valorisation-hsj, Limited Partnership, Montréal, CA;

Inventors:

Élie Haddad, Hampstead, CA;

Panojot Bifsha, Montréal, CA;

Aurélien Colamartino, Montréal, CA;

Kathie Béland, Montréal, CA;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/63 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); C07K 14/725 (2006.01); C12N 5/0781 (2010.01); C12N 5/0783 (2010.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/421 (2025.01); A61K 40/4212 (2025.01); A61K 40/4258 (2025.01); C07K 14/7051 (2013.01); C12N 5/0635 (2013.01); C12N 5/0636 (2013.01); C12N 5/0646 (2013.01); A61K 2239/47 (2023.05); A61K 2239/48 (2023.05); C12N 2740/15043 (2013.01); C12N 2830/15 (2013.01);
Abstract

New synthetic expression cassettes comprising a minimal promoter and a cell-specific enhancer for expression of a nucleic acid of interest in one or more specific cell subtypes are disclosed. Vectors and host cells comprising such synthetic expression cassettes are also disclosed. The application also discloses methods for expressing a nucleic acid of interest, such as a nucleic acid encoding a chimeric antigen receptor (CAR), in a cell and for treating diseases or conditions such as cancers and genetic diseases using the synthetic expression cassettes, vectors and cells.


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