The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2025
Filed:
Jun. 24, 2024
Camp4 Therapeutics Corporation, Cambridge, MA (US);
Alfica Sehgal, Belmont, MA (US);
Bryan J. Matthews, Somerville, MA (US);
David A. Bumcrot, Belmont, MA (US);
Justin A. Caravella, Cambridge, MA (US);
Mario Esteban Contreras Gamboa, Cambridge, MA (US);
Rachana S. Kelkar, Malden, MA (US);
Yun Joon Jung, Lexington, MA (US);
Yuting Liu, Lexington, MA (US);
Rutuja Sudhakar Pai, Charlestown, MA (US);
Subhadeep Roy, Lafayette, CO (US);
Yuchun Guo, Framingham, MA (US);
CAMP4 Therapeutics Corporation, Cambridge, MA (US);
Abstract
Described herein are methods of modulating gene transcription using antisense oligonucleotides (ASOs) targeting regulatory RNAs, such as promoter-associated RNAs and enhancer RNAs. These methods are useful for modulating the levels of gene products, for example, increasing expression of Carbamoyl-Phosphatase Synthetase 1 (CPS1), thereby treating diseases associated with aberrant gene expression.