The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2025
Filed:
May. 24, 2019
Applicant:
Wake Forest University Health Sciences, Winston-Salem, NC (US);
Inventor:
William H. Gmeiner, Yadkinville, NC (US);
Assignee:
Wake Forest University Health Sciences, Winston-Salem, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01); A61P 35/04 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 9/0019 (2013.01); A61K 45/06 (2013.01); A61P 35/04 (2018.01); C07H 21/04 (2013.01);
Abstract
Novel cytotoxic fluoropyrimidine polymers for treating cancer (e.g., colorectal cancer (CRC)) in a subject (e.g., a subject having cancer) are nucleic acid molecules including 5-fluoro-2'deoxyuridine monophosphate (FdUMP)[10] having a polyethylene glycol (PEG) spacer appended to the 5′ terminus and a cytarabine (AraC) nucleotide appended to 3′termius. These novel cytotoxic fluoropyrimidine polymers may be used in compositions, kits and methods for treating advanced and high-risk cancers, including CRC.