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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12319671 B1

PDFFull Text
Date of Patent:
Jun. 03, 2025

Filed:

Jun. 01, 2020

1-pyrazolyl, 5-, 6-disubstituted indazole derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof

Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Hua Zhou, Acton, MA (US);

John J. Acton, Iii, Cranford, NJ (US);

Michael J. Ardolino, Arlington, MA (US);

Yi-Heng Chen, Whippany, NJ (US);

Peter H. Fuller, Ashland, MA (US);

Anmol Gulati, Watertown, MA (US);

Rebecca Elizabeth Johnson, Oakland, CA (US);

William P. Kaplan, Boston, MA (US);

Solomon D. Kattar, Wakefield, MA (US);

Mitchell H. Keylor, Malden, MA (US);

Derun Li, West Roxbury, MA (US);

Kaitlyn Marie Logan, Boston, MA (US);

Min Lu, Brookline, MA (US);

Gregori J. Morriello, Randolph, NJ (US);

Santhosh F. Neelamkavil, Edison, NJ (US);

Barbara Pio, West Orange, NJ (US);

Nunzio Sciammetta, Sudbury, MA (US);

Vladimir Simov, South Boston, MA (US);

Jing Su, Scotch Plains, NJ (US);

Luis Torres, Norwood, MA (US);

Xin Yan, Newton, MA (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:

Sylvia A. Ayler

Catherine Fitch

Primary Examiner:

Clinton A Brooks

Assistant Examiner:

Kendall Nicole Heitmeier

Int. Cl.
CPC ...
C07D 405/14 (2006.01); A61P 25/16 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 471/04 (2006.01); C07D 471/10 (2006.01); C07D 487/04 (2006.01); C07D 487/08 (2006.01); C07D 487/10 (2006.01); C07D 491/107 (2006.01); C07D 498/04 (2006.01); C07D 498/08 (2006.01);
U.S. Cl.
CPC ...
C07D 405/14 (2013.01); A61P 25/16 (2018.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 409/14 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01); C07D 498/04 (2013.01); C07D 498/08 (2013.01);
Abstract

The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

Find Patent Forward Citations

Zhou, Hua. (2025). 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof (U.S. Patent No. 12319671). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12319671

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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