The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2025
Filed:
Mar. 26, 2020
Accendatech Co. Ltd., Tianjin, CN;
Nankai University, Tianjin, CN;
Zhonghua Li, Tianjin, CN;
Junbo Gong, Tianjin, CN;
Baohong Hou, Tianjin, CN;
Songgu Wu, Tianjin, CN;
Yue Chen, Tianjin, CN;
Chuanjiang Qiu, Tianjin, CN;
Xinghua Zhu, Tianjin, CN;
Jie Qi, Tianjin, CN;
Guiyan Wang, Tianjin, CN;
ACCENDATECH CO. LTD., Tianjin, CN;
NANKAI UNIVERSITY, Tianjin, CN;
Abstract
A hydrate of dimethylaminomicheliolide fumarate has a crystal form D, is high in crystallinity, smooth in particle surface, free of coalescence, high in bulk density and good in flowability, and has good stability and good reproducibility. Its preparation method includes: under a stirring action, adding dimethylamine micheliolide and fumaric acid into a mixed solvent system having a constant temperature of 30° C.-70° C. for reaction crystallization; and filtering after the reaction is finished, and drying filtered solid at normal pressure to obtain the crystal form D of the dimethylaminomicheliolide fumarate.