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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12319643 B1

PDFFull Text
Date of Patent:
Jun. 03, 2025

Filed:

Apr. 05, 2022

Ionizable compounds and compositions and uses thereof

Applicant:

Nitto Denko Corporation, Osaka, JP;

Inventors:

Roger Adami, Carlsbad, CA (US);

Hao Bai, San Diego, CA (US);

John Gaudette, Poway, CA (US);

Bharat Majeti, San Diego, CA (US);

Seiji Nukui, San Diego, CA (US);

Kwok Yin Tsang, Irvine, CA (US);

Hai Wang, San Diego, CA (US);

Haiqing Yin, San Marcos, CA (US);

Wenbin Ying, San Diego, CA (US);

Assignee:

Nitto Denko Corporation, Osaka, JP;

Attorney:

Knobbe, Martens, Olson & Bear, LLP

Primary Examiner:

Jane J Zara

Int. Cl.
CPC ...
C07C 271/16 (2006.01); A61K 9/127 (2006.01); A61K 9/51 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 47/16 (2006.01); A61K 47/22 (2006.01); A61K 47/24 (2006.01); C07C 237/08 (2006.01); C07C 237/16 (2006.01); C07C 237/50 (2006.01); C07D 205/04 (2006.01); C07D 207/09 (2006.01); C07D 207/12 (2006.01); C07D 211/74 (2006.01); C07D 211/82 (2006.01); C07D 211/86 (2006.01); C07F 9/06 (2006.01); C07F 9/10 (2006.01);
U.S. Cl.
CPC ...
C07C 271/16 (2013.01); A61K 9/127 (2013.01); A61K 9/5123 (2013.01); A61K 31/7105 (2013.01); A61K 31/713 (2013.01); A61K 47/16 (2013.01); A61K 47/22 (2013.01); A61K 47/24 (2013.01); C07C 237/08 (2013.01); C07C 237/16 (2013.01); C07C 237/50 (2013.01); C07D 205/04 (2013.01); C07D 207/09 (2013.01); C07D 207/12 (2013.01); C07D 211/74 (2013.01); C07D 211/82 (2013.01); C07D 211/86 (2013.01); C07F 9/06 (2013.01); C07F 9/106 (2013.01);
Abstract

Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

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