The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2025
Filed:
Dec. 05, 2019
Applicant:
Xcella Biosciences, Inc., Emeryville, CA (US);
Inventors:
Bob Chen, Menlo Park, CA (US);
Ming X. Tan, San Bruno, CA (US);
Arturo M. Escajeda, Oakland, CA (US);
Assignee:
XCELLA BIOSCIENCES, INC., Emeryville, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); B01L 9/00 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502715 (2013.01); B01L 3/50273 (2013.01); B01L 9/52 (2013.01); G01N 21/6428 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/16 (2013.01); B01L 2300/041 (2013.01); B01L 2300/048 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0819 (2013.01); B01L 2300/0829 (2013.01); B01L 2300/0851 (2013.01); B01L 2300/12 (2013.01); B01L 2400/049 (2013.01); G01N 2021/6439 (2013.01);
Abstract
Lateral loading methods of use in high-throughput methods for screening large populations of variant proteins are provided. The methods utilize a flow cell encompassing large-scale arrays of microcapillaries, where each microcapillary comprises a solution containing a variant protein, an immobilized target molecule, and a reporter element. Immobilized target molecules may include any molecule of interest, including proteins, nucleic acids, carbohydrates, and other biomolecules.