The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2025
Filed:
Mar. 10, 2018
Koc Universitesi, Istanbul, TR;
Sabanci Universitesi, Istanbul, TR;
Sabanci Universitesi Nanoteknoloji Araştirma VE Uygulama Merkezi, Istanbul, TR;
Havva Yagci Acar, Istanbul, TR;
Devrim Gozuacik, Istanbul, TR;
Ali Kosar, Istanbul, TR;
Ozlem Unal, Istanbul, TR;
Muhammed Kocak, Istanbul, TR;
Yunus Akkoc, Istanbul, TR;
Merve Zuvin, Istanbul, TR;
KOC UNIVERSITESI, Istanbul, TR;
SABANCI UNIVERSITESI, Istanbul, TR;
SABANCI UNIVERSITESI NANOTEKNOLOJI ARASTIRMA VE UYGULAMA MERKEZI, Istanbul, TR;
Abstract
The present invention relates to oligonucleotide carriers for oligonucleotide delivery to a subject to provide gene therapy. More particularly, the present invention relates to therapeutic nanoparticles for microRNA (miRNA) delivery to a subject. More particularly, the present invention relates to therapeutic nanoparticles wherein miRNA is bindable to biocompatible nanoparticles using natural gene carrier Argonaute (AGO) protein or a variant thereof. Optionally, therapeutic nanoparticles of the present invention additionally contain targeting moieties for targeting therapeutic nanoparticles to cancer cells and/or chemotherapeutic agents. Optionally, biocompatible nanoparticles are trackable nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPION), to provide multifunctional theranostics.