The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 2025
Filed:
Sep. 26, 2019
Applicant:
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
Nathanael S. Gray, Boston, MA (US);
David Scott, Newton, MA (US);
Zhengnian Li, Brookline, MA (US);
Benika J. Pinch, Brookline, MA (US);
Calla Olson, Brookline, MA (US);
Eric S. Fischer, Chestnut Hill, MA (US);
Radoslaw P. Nowak, Boston, MA (US);
Katherine A. Donovan, Brookline, MA (US);
Assignee:
DANA-FARBER CANCER INSTITUTE, INC., Boston, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/55 (2017.01); A61K 31/502 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01);
U.S. Cl.
CPC ...
A61K 47/55 (2017.08); A61K 31/502 (2013.01); A61K 31/519 (2013.01); A61K 47/545 (2017.08); A61K 47/555 (2017.08);
Abstract
Disclosed are bifunctional compounds (degraders) that target Wee1 tyrosine kinase for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.