The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 03, 2025

Filed:

Oct. 09, 2019
Applicant:

Hefei Institutes of Physical Science, Chinese Academy of Sciences, Anhui, CN;

Inventors:

Qingsong Liu, Anhui, CN;

Jing Liu, Anhui, CN;

Yun Wu, Anhui, CN;

Wenliang Wang, Anhui, CN;

Beilei Wang, Anhui, CN;

ZiPing Qi, Anhui, CN;

Junjie Wang, Anhui, CN;

Wenchao Wang, Anhui, CN;

Shuang Qi, Anhui, CN;

Li Wang, Anhui, CN;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/635 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61P 1/16 (2006.01); A61P 3/10 (2006.01); C07D 475/00 (2006.01); C07D 475/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/635 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61P 1/16 (2018.01); A61P 3/10 (2018.01); C07D 475/00 (2013.01); C07D 475/12 (2013.01);
Abstract

Disclosed is a kinase inhibitor, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite, or prodrug thereof. Also disclosed are a pharmaceutical composition comprising the kinase inhibitor and uses and methods for inhibiting the activity of one or more tyrosine kinases selected from MST1 and a mutant thereof in a cell or subject and for preventing or treating a disease related to MST1 or a mutant thereof in a subject by using the compound or composition.


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