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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12318371 B1

PDFFull Text
Date of Patent:
Jun. 03, 2025

Filed:

May. 13, 2020

Sustained-release microgel ointments with high drug loading and preparation methods and uses thereof

Applicant:

Jinan University, Guangdong, CN;

Inventors:

Hong Nie, Guangdong, CN;

Jianhao Zhao, Guangdong, CN;

Tao Zhu, Guangdong, CN;

Yan Wu, Guangdong, CN;

Hekun Zeng, Guangdong, CN;

Assignee:

JINAN UNIVERSITY, Guangdong, CN;

Attorney:

MUNCY, GEISSLER, OLDS & LOWE, P.C.

Primary Examiner:

Daniel R Carcanague

Assistant Examiner:

Jerica Katlynn Wilson

Int. Cl.
CPC ...
A61K 31/4375 (2006.01); A61K 9/06 (2006.01); A61K 31/352 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61P 17/04 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4375 (2013.01); A61K 9/06 (2013.01); A61K 31/352 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01); A61P 17/04 (2018.01);
Abstract

Disclosed is a sustained-release microgel ointment with high drug loading and a preparation method and use thereof. HTCC aqueous solution and HA aqueous solution are mixed uniformly to obtain the microgel aqueous solution. A drug is mixed with the microgel aqueous solution and concentrated, and a thickening agent is added and mixed evenly to obtain the sustained-release microgel ointment with high drug loading. The HA and HTCC form a microgel through electrostatic action, which is safe and convenient. The concentration step increases the concentration of the drug solution outside the microgel, which can increase the drug loading of the microgel. Drugs not loaded in the microgel inhibited the drug from being released from the microgel, prolonging the sustained release time of the microgel. The thickener transforms the drug-loaded microgel suspension into a paste, facilitating to applying the drug on the skin surface. Meanwhile, the drug added can be used at 100%, reducing the cost of microgel ointment. The ointment can be used to prepare a medicine for treating histamine-independent pruritus and analgesia.

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