The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 03, 2025

Filed:

Jul. 31, 2020
Applicant:

Acelot, Inc., Palo Alto, CA (US);

Inventors:

Ambuj K. Singh, Santa Barbara, CA (US);

Christian A. Lang, Santa Barbara, CA (US);

Assignee:

ACELOT, INC., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61P 25/16 (2006.01); A61K 31/137 (2006.01); A61K 31/167 (2006.01); A61K 31/277 (2006.01); A61K 31/357 (2006.01); A61K 31/40 (2006.01); A61K 31/452 (2006.01); A61K 31/495 (2006.01); A61K 31/5375 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/137 (2013.01); A61K 31/167 (2013.01); A61K 31/277 (2013.01); A61K 31/357 (2013.01); A61K 31/40 (2013.01); A61K 31/452 (2013.01); A61K 31/495 (2013.01); A61K 31/5375 (2013.01);
Abstract

The present invention provides small molecule drugs and pharmaceutical compositions for the treatment and prevention of diseases related to the formation of certain types of oligomers in a subject. More specifically, the drugs and compositions reduce or prevent the formation of oligomers formed from tau protein, TDP-43, Huntingtin's protein and/or alpha-synuclein. It further provides a method of reducing formation of or disrupting TDP-43, alpha-synuclein, Huntingtin's protein and/or tau protein oligomers in a subject, the method comprising the step of administering to the subject in need thereof a therapeutically effective amount of a pharmaceutical composition.


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