The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 27, 2025

Filed:

Jun. 08, 2017
Applicants:

The Broad Institute, Inc., Cambridge, MA (US);

Baylor College of Medicine, Houston, TX (US);

Inventors:

Erez Aiden, Houston, TX (US);

Olga Dudchenko, Houston, GA (US);

Aviva Aiden, Houston, TX (US);

Elena Stamenova, Cambridge, MA (US);

Sanjit Singh Batra, Houston, TX (US);

Arina Omer, Houston, TX (US);

Per Aspera Adastra, Houston, TX (US);

Neva Durand, Houston, TX (US);

Maxim Massenkoff, Cambridge, MA (US);

Sarah Nyquist, Cambridge, MA (US);

Anthony Tzen, Houston, TX (US);

Christopher Lui, Houston, TX (US);

Melanie Pham, Houston, TX (US);

Eric Lander, Cambridge, MA (US);

Assignees:

THE BROAD INSTITUTE, INC., Cambridge, MA (US);

BAYLOR COLLEGE OF MEDICINE, Houston, TX (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/48 (2006.01); C12Q 1/6869 (2018.01); G01N 33/50 (2006.01); G16B 5/10 (2019.01); G16B 15/10 (2019.01); G16B 30/20 (2019.01);
U.S. Cl.
CPC ...
G16B 5/10 (2019.02); C12Q 1/6869 (2013.01); G16B 15/10 (2019.02); G16B 30/20 (2019.02);
Abstract

Embodiments provide a method for sequencing and assembling long DNA genomes comprising generating a 3D contact map of chromatin loop structures in a target genome, the 3D contact map of chromatin loop structures defining spatial proximity relationships between genomic loci in the genome, and deriving a linear genomic nucleic acid sequence from the 3D map of chromatin loop structures.


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