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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12312627 B1

PDFFull Text
Date of Patent:
May. 27, 2025

Filed:

Jun. 23, 2016

Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds

Applicant:

Genomatica, Inc., San Diego, CA (US);

Inventors:

Priti Pharkya, San Diego, CA (US);

Anthony P. Burgard, Bellefonte, PA (US);

Stephen J. Van Dien, Encinitas, CA (US);

Robin E. Osterhout, San Diego, CA (US);

Mark J. Burk, San Diego, CA (US);

John D. Trawick, La Mesa, CA (US);

Michael P. Kuchinskas, Escondido, CA (US);

Brian Steer, San Diego, CA (US);

Stefan Andrae, San Diego, CA (US);

Amit Shah, San Diego, CA (US);

Assignee:

Genomatica, Inc., San Diego, CA (US);

Attorney:

Greenberg Traurig, LLP

Primary Examiner:

Paul J Holland

Int. Cl.
CPC ...
C12P 7/18 (2006.01); C07C 31/20 (2006.01); C07C 47/19 (2006.01); C07C 211/09 (2006.01); C07D 307/33 (2006.01); C12N 1/20 (2006.01); C12N 9/04 (2006.01); C12N 9/10 (2006.01); C12N 15/52 (2006.01); C12P 7/24 (2006.01); C12P 7/42 (2006.01); C12P 7/62 (2022.01); C12P 13/00 (2006.01); C12P 17/04 (2006.01); C12P 19/32 (2006.01);
U.S. Cl.
CPC ...
C12P 7/18 (2013.01); C07C 31/207 (2013.01); C07C 47/19 (2013.01); C07C 211/09 (2013.01); C07D 307/33 (2013.01); C12N 1/20 (2013.01); C12N 9/0006 (2013.01); C12N 9/13 (2013.01); C12N 15/52 (2013.01); C12P 7/24 (2013.01); C12P 7/42 (2013.01); C12P 7/62 (2013.01); C12P 13/001 (2013.01); C12P 13/005 (2013.01); C12P 17/04 (2013.01); C12P 19/32 (2013.01); C12Y 208/03 (2013.01);
Abstract

The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.

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