The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2025
Filed:
Apr. 04, 2024
Dalian University, Dalian, CN;
Qian Li, Dalian, CN;
Huiping Tan, Dalian, CN;
Baomin Feng, Dalian, CN;
Xiuping Li, Dalian, CN;
Liang Wang, Dalian, CN;
Yanghao Cheng, Dalian, CN;
Xiang Li, Dalian, CN;
Dapeng Wei, Dalian, CN;
Tuo Kan, Dalian, CN;
Chenyang Li, Dalian, CN;
Rongshuai Jiang, Dalian, CN;
DALIAN UNIVERSITY, Dalian, CN;
Abstract
The present invention relates to the field of genetic engineering and process engineering, and discloses an engineering strain producing cordycepin and its derivative 3'-deoxyinosine, its preparation method and application. The method includes: codon optimizing genes Cm1 and Cm2; gene amplification and fragment recovering; methanol-induced promoter and terminator fragments; and inserting the genes into an expression vector and then transferring tofor screening to obtain the engineering strain ofof the present invention. The engineering strain can be applied to production of cordycepin and its derivative. The engineering strain prepared by the preparation method of the present invention has great advantages in producing cordycepin and its derivative. Due to the use of unique strains ofwhich have unique Cm1 and Cm2 genes, the efficiency of cordycepin production is greatly improved, and subsequently the green process of producing cordycepin and its derivative 3′-deoxyinosine with carbon dioxide can be realized.