The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2025
Filed:
Jun. 27, 2019
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Hunter F. Malanson, Wallingford, CT (US);
Kyle A. Zingaro, Southington, CT (US);
Anjil Giri, Hamden, CT (US);
Justin Weaver, Manchester, CT (US);
Abraham Friedman, West Hartford, CT (US);
Jeffrey William Hunter, Wallingford, CT (US);
Saranya Sivanandam, Norwalk, CT (US);
Jeffrey Zugates, Hamden, CT (US);
Rahul Godawat, Woodbridge, CT (US);
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Abstract
The present application relates to a method of producing an anti-C5 antibody (ravulizumab), wherein the method comprises: —culturing mammalian cells comprising a nucleic acid encoding the anti-C5 antibody in a cell culture production medium—Performing two or more steps selected from the group consisting of: a recovery step; purification by Protein A affinity chromatography, a low pH viral inactivation step; Purification by cation exchange chromatography; Purification by anion exchange chromatography; a virus reduction filtration step; and a concentration and diafiltration step.