The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 27, 2025
Filed:
Feb. 28, 2024
Applicant:
Avilar Therapeutics, Inc., Waltham, MA (US);
Inventors:
Jason Allan Wiles, Madison, CT (US);
Srinivasa Karra, Pembrooke, MA (US);
Mark George Saulnier, Higganum, CT (US);
Jesse Jingyang Chen, Lexington, MA (US);
Kevin Tyler Sprott, Needham, MA (US);
Soumya Ray, Quincy, MA (US);
Assignee:
Avilar Therapeutics, Inc., Waltham, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 417/12 (2006.01); C07H 5/06 (2006.01); C07H 17/02 (2006.01);
U.S. Cl.
CPC ...
C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 417/12 (2013.01); C07H 5/06 (2013.01); C07H 17/02 (2013.01);
Abstract
Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.