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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12312339 B1

PDFFull Text
Date of Patent:
May. 27, 2025

Filed:

Aug. 18, 2023

Polo like kinase 4 inhibitors

Applicant:

Oric Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Chudi Ndubaku, Montreal, CA;

Jared Thomas Moore, San Rafael, CA (US);

Paul Anthony Gibbons, San Francisco, CA (US);

Jae Hyuk Chang, Alameda, CA (US);

F. Anthony Romero, Redwood City, CA (US);

Xiaohui Du, Belmont, CA (US);

Hiroyuki Kawai, Pacifica, CA (US);

Stephane Ciblat, Montreal, CA;

Hong Wang, Montreal, CA;

Vincent Albert, Montreal, CA;

Lea Constantineau-Forget, Montreal, CA;

Hugo De Almeida Silva, Montreal, CA;

Dilan Emine Polat, Montreal, CA;

Amit Nayyar, Montreal, CA;

Daniel Gordon Michael Shore, San Mateo, CA (US);

Kejia Wu, South San Francisco, CA (US);

Joanne Tan, San Mateo, CA (US);

Assignee:

ORIC PHARMACEUTICALS, INC., South San Francisco, CA (US);

Attorney:

WILSON SONSINI GOODRICH & ROSATI

Primary Examiner:

Kahsay Habte

Int. Cl.
CPC ...
C07D 403/14 (2006.01); A61K 31/416 (2006.01); A61K 31/4439 (2006.01); A61K 31/497 (2006.01); A61K 31/513 (2006.01); A61K 31/5377 (2006.01); A61K 31/553 (2006.01); A61K 31/675 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 491/048 (2006.01); C07D 491/107 (2006.01); C07D 498/04 (2006.01); C07D 498/08 (2006.01); C07F 9/6558 (2006.01);
U.S. Cl.
CPC ...
C07D 403/14 (2013.01); A61K 31/416 (2013.01); A61K 31/4439 (2013.01); A61K 31/497 (2013.01); A61K 31/513 (2013.01); A61K 31/5377 (2013.01); A61K 31/553 (2013.01); A61K 31/675 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 491/048 (2013.01); C07D 491/107 (2013.01); C07D 498/04 (2013.01); C07D 498/08 (2013.01); C07F 9/65583 (2013.01);
Abstract

Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

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