The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 27, 2025

Filed:

Feb. 03, 2023
Applicant:

Modernatx, Inc., Cambridge, MA (US);

Inventors:

Kerry E. Benenato, Cambridge, MA (US);

Mark Cornebise, Arlington, MA (US);

Edward Hennessy, Cambridge, MA (US);

Ellalahewage S. Kumarasinghe, Cambridge, MA (US);

Assignee:

ModernaTX, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 229/24 (2006.01); A61K 9/127 (2006.01); A61K 9/1272 (2025.01); A61K 31/713 (2006.01); A61K 47/54 (2017.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07C 229/24 (2013.01); A61K 9/1272 (2013.01); A61K 31/713 (2013.01); A61K 47/543 (2017.08); A61K 48/0033 (2013.01); A61K 48/005 (2013.01);
Abstract

The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.


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