The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 27, 2025

Filed:

Jan. 17, 2025
Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Dino Di Carlo, Los Angeles, CA (US);

Chueh-Yu Wu, Los Angeles, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
B01L 3/02 (2006.01); B01L 3/00 (2006.01); C12N 1/04 (2006.01); C12N 5/071 (2010.01); C12N 5/0783 (2010.01); C12Q 1/6806 (2018.01); G01N 33/543 (2006.01);
U.S. Cl.
CPC ...
B01L 3/0262 (2013.01); B01L 3/502715 (2013.01); B01L 3/502784 (2013.01); C12N 1/04 (2013.01); C12N 5/0625 (2013.01); C12N 5/0636 (2013.01); C12Q 1/6806 (2013.01); G01N 33/5432 (2013.01); B01L 2300/021 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/0896 (2013.01);
Abstract

Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.


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