The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 27, 2025

Filed:

Jun. 30, 2023
Applicant:

Nitto Denko Corporation, Osaka, JP;

Inventors:

Roger Adami, Carlsbad, CA (US);

Yuwei Wang, Oceanside, CA (US);

Haiqing Yin, San Marcos, CA (US);

Liping Wang, Carlsbad, CA (US);

Dong Liu, Irvine, CA (US);

Wenbin Ying, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/16 (2006.01); A61K 9/1271 (2025.01); A61K 9/14 (2006.01); A61K 9/19 (2006.01); A61K 9/51 (2006.01); A61K 31/713 (2006.01); A61K 47/26 (2006.01); A61K 47/36 (2006.01); A61K 47/40 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 9/19 (2013.01); A61K 9/1271 (2013.01); A61K 9/145 (2013.01); A61K 9/146 (2013.01); A61K 9/5123 (2013.01); A61K 31/713 (2013.01); A61K 47/26 (2013.01); A61K 47/36 (2013.01); A61K 47/40 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01);
Abstract

Compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.


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