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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12310996 B1

PDFFull Text
Date of Patent:
May. 27, 2025

Filed:

Feb. 13, 2024

Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome

Applicant:

Board of Regents, the University of Texas System, Austin, TX (US);

Inventors:

Jennifer Wargo, Houston, TX (US);

Vancheswaran Gopalakrishnan, Houston, TX (US);

Assignee:

BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);

Attorney:

STERNE, KESSLER, GOLDSTEIN & FOX P.L.L.C.

Primary Examiner:

Kade Ariani

Int. Cl.
CPC ...
A61K 35/741 (2015.01); A61K 9/00 (2006.01); A61K 35/00 (2006.01); A61K 35/17 (2025.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); C12N 1/20 (2006.01); C12Q 1/04 (2006.01);
U.S. Cl.
CPC ...
A61K 35/741 (2013.01); A61K 9/0053 (2013.01); A61K 35/17 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C12N 1/20 (2013.01); C12Q 1/04 (2013.01); A61K 2035/115 (2013.01);
Abstract

Provided herein are methods and compositions for the treatment of cancer by modulating the microbiome to enhance the efficacy of immune checkpoint blockade. The microbiome may be modulated by the administration of butyrate and/or butyrate-producing bacteria. Also provided herein are methods of determining a response to an immune checkpoint inhibitor by identifying if a subject has a favorable microbial profile.

Find Patent Forward Citations

Wargo, Jennifer. (2025). Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome (U.S. Patent No. 12310996). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12310996

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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