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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12310988 B1

PDFFull Text
Date of Patent:
May. 27, 2025

Filed:

Apr. 17, 2024

Bcma chimeric antigen receptors and uses thereof

Applicants:

Board of Regents, the University of Texas System, Austin, TX (US);

Takeda Pharmaceutical Company Limited, Osaka, JP;

Inventors:

Katy Rezvani, Houston, TX (US);

Rafet Basar, Houston, TX (US);

Paul Lin, Houston, TX (US);

Michael David Curley, Cambridge, MA (US);

LeeAnn Talarico, Cambridge, MA (US);

Prashanth Vishwanath, Cambridge, MA (US);

James Wilson Meador, Iii, Cambridge, MA (US);

Assignees:

Board of Regents, The University of Texas System, Austin, TX (US);

Takeda Pharmaceutical Company Limited, Osaka, JP;

Attorney:

Proskauer Rose LLP

Primary Examiner:

Hong Sang

Int. Cl.
CPC ...
A61K 35/17 (2025.01); A61K 9/00 (2006.01); A61K 40/11 (2025.01); A61K 40/15 (2025.01); A61K 40/42 (2025.01); A61P 35/00 (2006.01); C07K 14/54 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 9/0019 (2013.01); A61K 40/11 (2025.01); A61K 40/15 (2025.01); A61K 40/4215 (2025.01); A61P 35/00 (2018.01); C07K 14/5443 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 16/2878 (2013.01); C12N 15/85 (2013.01); A61K 2239/13 (2023.05); A61K 2239/21 (2023.05); A61K 2239/22 (2023.05); C07K 2317/53 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01); C12N 15/62 (2013.01);
Abstract

The present application provides BCMA targeting chimeric antigen receptor (CAR) comprising a BCMA binding region and an intracellular costimulatory domain derived from DAP10. Further provided are engineered immune effector cells (such as NK cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Find Patent Forward Citations

Rezvani, Katy. (2025). Bcma chimeric antigen receptors and uses thereof (U.S. Patent No. 12310988). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12310988

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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