The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 27, 2025

Filed:

Jun. 12, 2023
Applicant:

Yale University, New Haven, CT (US);

Inventors:

Mark Fields, New Haven, CT (US);

Lucian Del Priore, Tarrytown, NY (US);

Huey Cai, Montville, NJ (US);

Denton Hoyer, West Haven, CT (US);

Assignee:

YALE UNIVERSITY, New Haven, CT (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 31/519 (2006.01); A61K 47/40 (2006.01); A61K 9/19 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61K 47/40 (2013.01); A61K 9/0051 (2013.01); A61K 9/19 (2013.01);
Abstract

The invention provides a method of treating retinal degenerations, such as but not limited to anterior segment ocular disorders and/or age-related macular degeneration (AMD), in a subject, the method comprising administering to the subject a pharmaceutical composition comprising an effective amount of a compound of formula (1) or formula (2). In a further aspect, the invention provides compounds of formula (2). In certain embodiments, the compounds of the invention prevent or minimize cellular assault, such as oxidative stress-related cellular assault, and/or promote cell viability.


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