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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12310928 B1

PDFFull Text
Date of Patent:
May. 27, 2025

Filed:

Nov. 16, 2020

Enthesis healing

Applicant:

University of Utah Research Foundation, Salt Lake City, UT (US);

Inventors:

Robert Z. Tashjian, Salt Lake City, UT (US);

Peter N. Chalmers, Salt Lake City, UT (US);

T. Wade Fallin, Hyde Park, UT (US);

James M. Hotaling, Salt Lake City, UT (US);

Assignee:

UNIVERSITY OF UTAH RESEARCH FOUNDATION, Salt Lake City, UT (US);

Attorney:

Workman Nydegger

Primary Examiner:

Sahar Javanmard

Int. Cl.
CPC ...
A61K 31/05 (2006.01); A61B 17/00 (2006.01); A61B 17/04 (2006.01); A61B 17/06 (2006.01); A61K 9/70 (2006.01); A61K 45/06 (2006.01); A61L 17/00 (2006.01); A61P 19/00 (2006.01); A61P 21/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/05 (2013.01); A61K 9/7023 (2013.01); A61K 45/06 (2013.01); A61L 17/005 (2013.01); A61P 19/00 (2018.01); A61P 21/00 (2018.01); A61B 2017/00893 (2013.01); A61B 17/0401 (2013.01); A61B 17/06166 (2013.01);
Abstract

Disclosed are devices and methods for improving healing of an enthesis. An effective amount of a composition comprising one or more sex steroids and/or sex steroid equivalents is locally administered at the site of a repaired enthesis. The composition causes upregulation of one or more chondrogenic, angiogenic, and/or tendon modulation genes, resulting in improved healing of the enthesis. The improved enthesis healing occurs even where the subject has normal levels of sex hormones.

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