The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 27, 2025

Filed:

Nov. 22, 2019
Applicant:

Provincial Health Services Authority, Vancouver, CA;

Inventors:

Haishan Zeng, Vancouver, CA;

Zhenguo Wu, Vancouver, CA;

Harvey Lui, Vancouver, CA;

Yunxian Tian, Vancouver, CA;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61B 5/00 (2006.01); G02B 21/00 (2006.01); G02B 21/36 (2006.01); G02B 27/64 (2006.01);
U.S. Cl.
CPC ...
A61B 5/0075 (2013.01); A61B 5/0071 (2013.01); A61B 5/444 (2013.01); G02B 21/0028 (2013.01); G02B 21/0048 (2013.01); G02B 21/006 (2013.01); G02B 21/0076 (2013.01); G02B 21/367 (2013.01); G02B 27/646 (2013.01);
Abstract

Methods and apparatus for obtaining 3D imaging of tissue involve scanning a focused laser beam in xz planes to obtain a set of xz plane images spaced apart in a y direction. The xz plane images are processed to correct distortions and motions and combined to provide 3D image data. Surface flatting is optionally performed. Imaging may be performed using a femtosecond (fs) laser beam. Different components of light returning from the tissue may be detected and processed to yield plural co-registered images using different imaging modalities, for example, reflective confocal microscopy (RCM), two photon fluorescence (TPF) and second harmonic generation (SHG).


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