The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2025
Filed:
Mar. 22, 2019
National University Corporation Tokyo Medical and Dental University, Tokyo, JP;
Takanori Yokota, Tokyo, JP;
Tetsuya Nagata, Tokyo, JP;
Hideki Furukawa, Kanagawa, JP;
Yasuo Nakagawa, Kanagawa, JP;
Takatoshi Yogo, Kanagawa, JP;
Ryosuke Tokunoh, Kanagawa, JP;
Shigekazu Sasaki, Kanagawa, JP;
Kosuke Hidaka, Kanagawa, JP;
Tomohiro Seki, Kanagawa, JP;
Kenichi Miyata, Kanagawa, JP;
Yusuke Adachi, Kanagawa, JP;
Naoto Arimura, Kanagawa, JP;
Abstract
The object of the present invention is to provide a nucleic acid agent that can be efficiently delivered to the nervous system, particularly the central nervous system to which the BBB mechanism prevents drug delivery, and can produce an antisense effect on a target transcriptional product at the delivered site, and a composition comprising the same. Provided is a double-stranded nucleic acid complex formed by annealing a first nucleic acid strand capable of hybridizing to part of a target transcriptional product, and has an antisense effect on the target transcriptional product, to a second nucleic acid strand comprising a base sequence complementary to the first nucleic acid strand, and is bound to tocopherol or an analog thereof, cholesterol or an analog thereof, or a substituted or unsubstituted Calkyl group, a substituted or unsubstituted Calkenyl group, or a substituted or unsubstituted Calkoxy group.