The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2025
Filed:
Nov. 13, 2019
Hangzhou Sumgen Biotech Co., Ltd., Hangzhou, CN;
Sumgen Mab (Beijing) Biotech Co., Ltd., Beijing, CN;
Ming Lv, Hangzhou, CN;
Xiaoran Ding, Hangzhou, CN;
Shiwei Miao, Hangzhou, CN;
Bin Tan, Hangzhou, CN;
Xuegong Wang, Hangzhou, CN;
HANGZHOU SUMGEN BIOTECH CO., LTD., Hangzhou, CN;
SUMGEN MAB (BEIJING) BIOTECH CO., LTD., Beijing, CN;
Abstract
Provided is a fusion protein, comprising a first binding domain that specifically binds a tumor-associated antigen, and a second binding domain that specifically binds a CD47 protein, wherein the second binding domain comprises a mutant of a human SIRPα variant 1. Also provided are an immunoconjugate, nucleic acid molecules, vectors, compositions, and cells related to the fusion protein and preparation methods therefor, and the uses thereof in the preparation of medicaments.