The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2025
Filed:
Oct. 22, 2020
Applicant:
University of Washington, Seattle, WA (US);
Inventors:
Robert A. Langan, Seattle, WA (US);
Scott Boyken, Seattle, WA (US);
David Baker, Seattle, WA (US);
Walter Novak, Seattle, WA (US);
Marc Joseph Lajoie, Seattle, WA (US);
Alfredo Quijano Rubio, Seattle, WA (US);
Assignee:
UNIVERSITY OF WASHINGTON, Seattle, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
C07K 14/001 (2013.01); A61K 47/6949 (2017.08); C07K 2319/40 (2013.01); C07K 2319/60 (2013.01); C07K 2319/70 (2013.01);
Abstract
Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive ('off') state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.