The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2025
Filed:
Nov. 16, 2023
Applicant:
Jazz Pharmaceuticals Ireland Limited, Dublin, IE;
Inventors:
Andrew Belfield, Macclesfield, GB;
Clifford David Jones, Macclesfield, GB;
Jean-François Margathe, Macclesfield, GB;
Chiara Colletto, Macclesfield, GB;
Assignee:
Jazz Pharmaceuticals Ireland Limited, Dublin, IE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 405/14 (2006.01); A61K 31/4433 (2006.01); A61K 45/06 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 45/06 (2013.01); C07D 405/14 (2013.01);
Abstract
The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.