The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 2025
Filed:
Apr. 17, 2019
Pontificia Universidad Catolica DE Chile, Santiago, CL;
Carlos Enrique Fardella Bello, Santiago, CL;
Carlos Fernando Lagos Arévalo, Santiago, CL;
Andrea Paola Vecchiola Cárdenas, Santiago, CL;
Fidel Alejandro Allende Sanzana, Santiago, CL;
Benjamin Manuel Diethelm Varela, Santiago, CL;
Gonzalo Ivan Recabarren Gajardo, Santiago, CL;
Pablo Marcelo González Cisterna, Santiago, CL;
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Santiago, CL;
Abstract
The present invention relates to compounds derived from adamantyl oxadiazoles and the pharmaceutically acceptable solvates, hydrates and salts of same. These compounds are suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1), as well as in the production of a drug for treating conditions and diseases such as high blood pressure, obesity, dyslipidaemia, type 2 diabetes, insulin resistance, glaucoma, metabolic syndrome, cognitive disorders, osteoporosis, immune disorders, depression and other conditions. Also provided is a pharmaceutical composition comprising the compounds and a method for preparing said composition.